The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons.

@article{Jiang2005TheEE,
  title={The excitoprotective effect of N-methyl-D-aspartate receptors is mediated by a brain-derived neurotrophic factor autocrine loop in cultured hippocampal neurons.},
  author={Xueying Jiang and Feng Tian and Karen M. Mearow and Peter Okagaki and Robert H. Lipsky and Ann M. Marini},
  journal={Journal of neurochemistry},
  year={2005},
  volume={94 3},
  pages={713-22}
}
The neuroprotective effect and molecular mechanisms underlying preconditioning with N-methyl-D-aspartate (NMDA) in cultured hippocampal neurons have not been described. Pre-incubation with subtoxic concentrations of the endogenous neurotransmitter glutamate protects vulnerable neurons against NMDA receptor-mediated excitotoxicity. As a result of physiological preconditioning, NMDA significantly antagonizes the neurotoxicity resulting from subsequent exposure to an excitotoxic concentration of… CONTINUE READING