The evolving role of catumaxomab in gastric cancer

  title={The evolving role of catumaxomab in gastric cancer},
  author={Florian Lordick and Katja Ott and J{\"u}rgen Weitz and Dirk J{\"a}ger},
  journal={Expert Opinion on Biological Therapy},
  pages={1407 - 1415}
Background: Gastric cancer is a condition with a high medical need. Even after R0 resection the rate of peritoneal and other distant site recurrences is high. Novel therapeutic approaches include trifunctional antibodies (trAb) that recruit and activate different types of immune effector cells at the tumour site. The trAb catumaxomab has dual antigen specificity for epithelial cell adhesion molecule and CD3 and binds to Fcγ-receptor-positive accessory cells. Intraperitoneal administration of… 

Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action

A strong dose-dependent antitumor response mediated by catumaxomab is found, with volume-decreased or completely destroyed tumor spheroids together with a massive immune cell infiltration and decreased signals for cancer cell viability and clonogenicity.

Advanced gastric cancer--slow but steady progress.

Is Preoperative Chemotherapy Followed by Surgery the Appropriate Treatment for Signet Ring Cell Containing Adenocarcinomas of the Esophagogastric Junction and Stomach?

Although response to neoadjuvant chemotherapy is rare in SRC, it is associated with improved outcome, and chemotherapy might not generally be abandoned in S RC, so a stratification based on SRC should be included in clinical trials.


The analysis revealed chemotherapy followed by surgery to be the preferred protocol for treatment of gastric cancer(primary optio n), the exact selection of the agents and surgery involved being debatable.

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How the basic principles of neoadjuvant therapy translate into clinical practice is summarized and a review of current developmental perspectives in this field is given.

Magen- und Adenokarzinome des ösophagogastralen Übergangs

Neoadjuvant therapy seeks to achieve downsizing of the primary tumor, lowering of the T and N categories and eradication of micrometastases and survival can be improved by neoadjuant chemotherapy.

Neoadjuvante und adjuvante Therapie des Magen- und Ösophaguskarzinoms

It is shown that multimodal treatment can lead to better outcomes than surgery alone, and patients with locally advanced gastric and oesophageal cancers should always be referred to an experienced high-volume centre where findings are discussed by a multidisciplinary tumour board.

Multimodale Therapie bei Karzinomen des gastroösophagealen Übergangs (GÖÜ)

It has been shown that multimodal treatment can improve the outcome in comparison to surgery alone and Adenothat perioperative chemotherapy significantly improves the survival of patients with adenocarcinoma of the stomach and the gastroesophageal cancers.



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Intraperitoneal treatment with the trifunctional antibody catumaxomab may be an attractive option for treatment of patients with peritoneal carcinomatosis due to GI-tract cancer and convincing results have to be further investigated in clinical phase II/III trials.

Intraoperative, adjuvant treatment of gastric cancer with the trifunctional antibody catumaxomab compared to surgery alone: A phase II study

This data indicates that the trifunctional antibody catumaxomab (anti-EpCAM × anti-CD) combination may be a viable treatment option for gastric cancer patients with a high risk of peritoneal recurrence after surgery.

Intraoperative Immuntherapie mit dem trifunktionalen Antikörper Catumaxomab bei Patienten mit fortgeschrittenem Magen-, Colon- und Pankreaskarzinom: Ergebnisse einer Phase I Pilotstudie

Intraoperative immunotherapy with trifunctional antibodies is technically feasible and safe up to 20 µg even in patients with extended tumor surgery, which offers promising opportunities to prevent tumor recurrence and peritoneal carcinomatosis in GI-tract cancer.

Treatment of non-small cell lung cancer patients with the trifunctional monoclonal antibody catumaxomab (anti-EpCAM × anti-CD3): a phase I study

Five micrograms of catumaxomab with a pre-medication of 40 mg dexamethasone and antihistamines can be recommended as first dose for i.v. therapy consisting of multiple catumxomab infusions for patients with NSCLC.

Treatment of ovarian cancer patients with malignant ascites using the trifunctional antibody catumaxomab: Results of a phase II/III study

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A clinical correlation was found between the occurrence of peritoneal dissemination and tumour stage pT3, pN2, G3, cancer of the whole stomach and cancer at the anastomotic site after partial gastric resection.

Advanced gastric cancer with or without peritoneal carcinomatosis treated with hyperthermic intraperitoneal chemotherapy: a single western center experience.

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