The evolutionary significance of cis-regulatory mutations

@article{Wray2007TheES,
  title={The evolutionary significance of cis-regulatory mutations},
  author={Gregory A. Wray},
  journal={Nature Reviews Genetics},
  year={2007},
  volume={8},
  pages={206-216}
}
  • G. Wray
  • Published 1 March 2007
  • Biology
  • Nature Reviews Genetics
For decades, evolutionary biologists have argued that changes in cis-regulatory sequences constitute an important part of the genetic basis for adaptation. Although originally based on first principles, this claim is now empirically well supported: numerous studies have identified cis-regulatory mutations with functionally significant consequences for morphology, physiology and behaviour. The focus has now shifted to considering whether cis-regulatory and coding mutations make qualitatively… 

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