The evolutionary scrambling and developmental unscrambling of germline genes in hypotrichous ciliates.

@article{Prescott1999TheES,
  title={The evolutionary scrambling and developmental unscrambling of germline genes in hypotrichous ciliates.},
  author={David M. Prescott},
  journal={Nucleic acids research},
  year={1999},
  volume={27 5},
  pages={1243-50}
}
Genes in the germline (micronuclear) genome of hypotrichous ciliates are interrupted by multiple, short, non-coding, AT-rich sequences called internal eliminated segments, or IESs. During conversion of a micronucleus to a somatic nucleus (macronucleus) after cell mating, all IESs are excised from the germline genes and the gene segments, called macronuclear-destined segments, or MDSs, are spliced. Excision of the approximately 150 000 IESs from a haploid germline genome in Oxytricha nova… CONTINUE READING
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Prescott,D.M. and Greslin,A.F

  • M. DuBois, D. M. Prescott
  • Mol. Microbiol.,
  • 1989

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