The evolutionary paradox and the missing heritability of schizophrenia

@article{vanDongen2013TheEP,
  title={The evolutionary paradox and the missing heritability of schizophrenia},
  author={Jenny van Dongen and Dorret I. Boomsma},
  journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics},
  year={2013},
  volume={162}
}
  • J. van Dongen, D. Boomsma
  • Published 1 March 2013
  • Psychology
  • American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Schizophrenia is one of the most detrimental common psychiatric disorders, occurring at a prevalence of approximately 1%, and characterized by increased mortality and reduced reproduction, especially in men. The heritability has been estimated around 70% and the genome‐wide association meta‐analyses conducted by the Psychiatric Genomics Consortium have been successful at identifying an increasing number of risk loci. Various theories have been proposed to explain why genetic variants that… 
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