The evolutionary origin of the vasopressin/V2-type receptor/aquaporin axis and the urine-concentrating mechanism

@article{Juul2012TheEO,
  title={The evolutionary origin of the vasopressin/V2-type receptor/aquaporin axis and the urine-concentrating mechanism},
  author={Kristian Vinter Juul},
  journal={Endocrine},
  year={2012},
  volume={42},
  pages={63-68}
}
In this mini-review, current evidence for how the vasopressin/V2-type receptor/aquaporin axis developed co-evolutionary as a crucial part of the urine-concentrating mechanism will be presented. The present-day human kidney, allowing the concentration of urine up to a maximal osmolality around 1200 mosmol kg−1—or urine to plasma osmolality ratio around 4—with essentially no sodium secreted is the result of up to 3 billion years evolution. Moving from aquatic to terrestrial habitats required… CONTINUE READING