The evolutionary origin of the HLA-DR3 haplotype

  title={The evolutionary origin of the HLA-DR3 haplotype},
  author={Vladimir Vincek and D. Klein and Felipe Figueroa and Věra Hauptfeld and Masanori Kasahara and Colm O'huigin and Bernard Mach and J. Klein},
The human HLA-DR3 haplotype consists of two functional genes (DRB1*03 and DRB3*01) and one pseudogene (DRB2), arranged in the order DRB1... DRB2... DRB3 on the chromosome. To shed light on the origin of the haplotype, we sequenced 1480 nucleotides of the HLA-DRB2 gene and aong stretches of two other genes, Gogo-DRB2 from a gorilla, “Sylvia” and Patr-DRB2 from a chimpanzee, “Hugo”. All three sequences (HLA-DRB2, Gogo-DRB2, Patr-DRB2) are pseudogenes. The HLA-DRB2 and Gogo-DRB2 pseudogenes lack… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 2 times over the past 90 days. VIEW TWEETS
11 Citations
49 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 11 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

The DRB subregion of the gorilla major histocompatibility complex: evidence for linkage disequilibrium conserved across species

  • M. Kasahara, D. Klein, V. Vincek, D. E. Sarapata, J. Klein
  • 1991
Highly Influential
4 Excerpts

Gorilla MhcDRB pseudogene orthologous to HLADRBVII 1

  • D. Klein, V. Vincek, M. Kasahara
  • Hum lmmunol
  • 1991

Phylogeny of primate Mhc DRB alleles

  • J. Klein, M. Kasahara, J. Gutknecht
  • Hum Immunol
  • 1991

WHO Committee for Factors of the HLA System : Nomenclature for Factors of the HLA System , 1990

  • J. A. T. Young, D. Wilkinson, W. F. Bodmer, J. Trowsdale
  • Immunogenetics
  • 1991

Similar Papers

Loading similar papers…