The evolutionary origin of hedgehog proteins

  title={The evolutionary origin of hedgehog proteins},
  author={Maja Adamska and David Q. Matus and Marcin Adamski and Kathryn M. Green and Daniel S. Rokhsar and Mark Q. Martindale and Bernard M. Degnan},
  journal={Current Biology},
Summary Animal development is orchestrated largely by diffusible ligands of the Wnt, TGF- β , hedgehog (Hh) and FGF signaling pathways, as well as cell-surface molecules, such as Notch, cadherins, integrins and the immunoglobulin-like proteins [1,2]. Here, we show that Hh proteins are likely to have evolved very early in metazoan evolution by domain shuffling. We identify in sponges and cnidarians a transmembrane protein, Hedgling, that contains the amino-terminal, signalling domain of Hh… Expand
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Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life
  • H. Roelink
  • Biology, Medicine
  • Journal of developmental biology
  • 2018
A sequence analysis of Hh proteins and their possible evolutionary precursors suggests that the evolution of modern Hh might have involved horizontal transfer of a bacterial gene coding of a Hh/DD-peptidase into a Cnidarian ancestor, recombining to give rise tomodern Hh. Expand
Sonic Hedgehog is a member of the Hh/DD-peptidase family that spans the eukaryotic and bacterial domains of life
Sequence analysis of Hh proteins and their possible evolutionary precursors suggest that the evolution of modern Hh might have involved horizontal transfer of a bacterial gene coding of a Hh/DD-peptidase into a Cnidarian ancestor, recombining to give rise to modern Shh. Expand
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The Hedgehog signaling domain was acquired from a prokaryote.
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An unusual choanoflagellate protein released by Hedgehog autocatalytic processing
It is argued that metazoan hedgehog genes evolved by fusion of two distinct genes, including Hoglet-N, which is deduced to be a secreted protein with an enormous threonine-rich domain of unprecedented size and purity and two polysaccharide-binding domains. Expand
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Cell adhesion in development: a complex signaling network.
  • J. Thiery
  • Biology, Medicine
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Findings confirm that a given cell-adhesion molecule can be implicated at different stages of development in processes as diverse as cell positioning, tissue patterning and compartmentalization, axon guidance and synaptogenesis. Expand
Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians.
It is shown that the full diversity of metazoan signaling pathways is represented in this phylum, as are antagonists previously known only in chordates, and many of the cnidarian ESTs match genes previously known in non-animal kingdoms. Expand
Whole mount in situ hybridization
1) Enzyme digestion Cut ~10μg of plasmid DNA with appropriate restriction enzyme (choose enzymes that create blunt end or 5’-overhang; 10U/μg DNA). Cut to completeness (>4 hours) to avoid rollingExpand