The evolutionary origin of hedgehog proteins

@article{Adamska2007TheEO,
  title={The evolutionary origin of hedgehog proteins},
  author={Maja Adamska and David Q. Matus and Marcin Adamski and Kathryn M. Green and Daniel S. Rokhsar and Mark Q. Martindale and Bernard M. Degnan},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={R836-R837}
}
Summary Animal development is orchestrated largely by diffusible ligands of the Wnt, TGF- β , hedgehog (Hh) and FGF signaling pathways, as well as cell-surface molecules, such as Notch, cadherins, integrins and the immunoglobulin-like proteins [1,2]. Here, we show that Hh proteins are likely to have evolved very early in metazoan evolution by domain shuffling. We identify in sponges and cnidarians a transmembrane protein, Hedgling, that contains the amino-terminal, signalling domain of Hh… Expand
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