The evolutionary origin of cardiac chambers.

  title={The evolutionary origin of cardiac chambers.},
  author={M. S. Sim{\~o}es-Costa and Michelle Vasconcelos and A. C. Sampaio and R. Cravo and V. L. Linhares and T. Hochgreb and C. Y. I. Yan and B. Davidson and J. Xavier-Neto},
  journal={Developmental biology},
  volume={277 1},
  • M. S. Simões-Costa, Michelle Vasconcelos, +6 authors J. Xavier-Neto
  • Published 2005
  • Biology, Medicine
  • Developmental biology
  • Identification of cardiac mechanisms of retinoic acid (RA) signaling, description of homologous genetic circuits in Ciona intestinalis and consolidation of views on the secondary heart field have fundamental, but still unrecognized implications for vertebrate heart evolution. [...] Key Result Analyzing chordates, lower and higher vertebrates, we propose a paradigm picturing vertebrate hearts as advanced circulatory pumps formed by segments, chambered or not, devoted to inflow or outflow.Expand Abstract
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