The evolutionary history of Cys-tRNACys formation.

  title={The evolutionary history of Cys-tRNACys formation.},
  author={Patrick O'Donoghue and Anurag Sethi and Carl R. Woese and Zaida Luthey-Schulten},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 52},
The recent discovery of an alternate pathway for indirectly charging tRNA(Cys) has stimulated a re-examination of the evolutionary history of Cys-tRNA(Cys) formation. In the first step of the pathway, O-phosphoseryl-tRNA synthetase charges tRNA(Cys) with O-phosphoserine (Sep), a precursor of the cognate amino acid. In the following step, Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep to Cys in a tRNA-dependent reaction. The existence of such a pathway raises several evolutionary questions… CONTINUE READING


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