The evolutionary functions of cardiac NOS/NO in vertebrates tracked by fish and amphibian paradigms.


During early ectotherm vertebrate evolution the heart was redesigned as a high pressure pump adapted to perfuse larger body sizes. To compensate the consequent higher organ complexity and heterogeneity (ventricular myoarchitecture and blood supply), conceivably the three principal cardiac cell components, the endocardium, the contractile myocardium and the… (More)
DOI: 10.1016/j.niox.2011.05.001


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