The evolutionary dynamics of repetitive DNA in eukaryotes

@article{Charlesworth1994TheED,
  title={The evolutionary dynamics of repetitive DNA in eukaryotes},
  author={B. Charlesworth and P. Sniegowski and W. Stephan},
  journal={Nature},
  year={1994},
  volume={371},
  pages={215-220}
}
  • B. Charlesworth, P. Sniegowski, W. Stephan
  • Published 1994
  • Biology, Medicine
  • Nature
  • Repetitive DNA sequences form a large portion of the genomes of eukaryotes. The 'selfish DNA' hypothesis proposes that they are maintained by their ability to replicate within the genome. The behaviour of repetitive sequences can result in mutations that cause genetic diseases, and confer significant fitness losses on the organism. Features of the organization of repetitive sequences in eukaryotic genomes, and their distribution in natural populations, reflect the evolutionary forces acting on… CONTINUE READING
    1,435 Citations

    Topics from this paper

    Repetitive DNA: Evolution
    • 2
    Concerted evolution: molecular mechanism and biological implications.
    • D. Liao
    • Biology, Medicine
    • American journal of human genetics
    • 1999
    • 344
    Repetitive DNA sequences in plant genomes
    • 6
    The ecology of the genome — mobile DNA elements and their hosts
    • 195
    Instabilities of triplet repeats: factors and mechanisms.
    • 11
    Evolution of Genome Organization
    • 1
    The role of selfish genetic elements in eukaryotic evolution
    • 348
    • PDF
    Genomic repetitive DNA elements of Trypanosoma cruzi.
    • 42

    References

    SHOWING 1-10 OF 83 REFERENCES
    Selfish genes, the phenotype paradigm and genome evolution
    • 1,625
    Mammalian chromosome structure.
    • 123
    Evolution of repeated DNA sequences by unequal crossover.
    • 1,038
    Recombination and the evolution of satellite DNA.
    • 68
    Evolution and consequences of transposable elements.
    • J. McDonald
    • Biology, Medicine
    • Current opinion in genetics & development
    • 1993
    • 205
    Selfish DNA: the ultimate parasite
    • 1,810
    Tandem-repetitive noncoding DNA: forms and forces.
    • W. Stephan
    • Biology, Medicine
    • Molecular biology and evolution
    • 1989
    • 112