The evolutionary appearance of non-cyanogenic hydroxynitrile glucosides in the Lotus genus is accompanied by the substrate specialization of paralogous β-glucosidases resulting from a crucial amino acid substitution.

@article{Lai2014TheEA,
  title={The evolutionary appearance of non-cyanogenic hydroxynitrile glucosides in the Lotus genus is accompanied by the substrate specialization of paralogous β-glucosidases resulting from a crucial amino acid substitution.},
  author={Daniela Lai and Maher Abou Hachem and Fran Robson and Carl Erik Olsen and Trevor L. Wang and Birger Lindberg M\oller and Adam M. Takos and Fred Rook},
  journal={The Plant journal : for cell and molecular biology},
  year={2014},
  volume={79 2},
  pages={299-311}
}
Lotus japonicus, like several other legumes, biosynthesizes the cyanogenic α-hydroxynitrile glucosides lotaustralin and linamarin. Upon tissue disruption these compounds are hydrolysed by a specific β-glucosidase, resulting in the release of hydrogen cyanide. Lotus japonicus also produces the non-cyanogenic γ- and β-hydroxynitrile glucosides rhodiocyanoside A and D using a biosynthetic pathway that branches off from lotaustralin biosynthesis. We previously established that BGD2 is the only… CONTINUE READING

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