The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair.

@article{Lin1998TheEC,
  title={The evolutionarily conserved zinc finger motif in the largest subunit of human replication protein A is required for DNA replication and mismatch repair but not for nucleotide excision repair.},
  author={Y L Lin and Mahmud K.K Shivji and Changmin Chen and Richard Kolodner and Richard D Wood and Anindya Dutta},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 3},
  pages={1453-61}
}
The largest subunit of the replication protein A (RPA) contains an evolutionarily conserved zinc finger motif that lies outside of the domains required for binding to single-stranded DNA or forming the RPA holocomplex. In previous studies, we showed that a point mutation in this motif (RPAm) cannot support SV40 DNA replication. We have now investigated the role of this motif in several steps of DNA replication and in two DNA repair pathways. RPAm associates with T antigen, assists the unwinding… CONTINUE READING

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