The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.

@article{Fabrizio2009TheEC,
  title={The evolutionarily conserved core design of the catalytic activation step of the yeast spliceosome.},
  author={Patrizia Fabrizio and Julia Dannenberg and Prakash Dube and Berthold Kastner and Holger Stark and Henning Urlaub and Reinhard L{\"u}hrmann},
  journal={Molecular cell},
  year={2009},
  volume={36 4},
  pages={593-608}
}
Metazoan spliceosomes exhibit an elaborate protein composition required for canonical and alternative splicing. Thus, the minimal set of proteins essential for activation and catalysis remains elusive. We therefore purified in vitro assembled, precatalytic spliceosomal complex B, activated B(act), and step 1 complex C from the simple eukaryote Saccharomyces cerevisiae. Mass spectrometry revealed that yeast spliceosomes contain fewer proteins than metazoans and that each functional stage is very… CONTINUE READING
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Formation of the yeast splicing complex A1 and association of the splicing factor PRP19 with the pre-mRNA are independent of the 30 region of the intron

  • S. C. Cheng
  • Nucleic Acids Res
  • 1994
Highly Influential
5 Excerpts

a 2009 Elsevier steps in the yeast splicing pathway , particularly assembly of the spliceosome

  • M. C. Wahl, C. L. Will, R. Lührmann
  • EMBO J .
  • 2009
Highly Influential
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steps in the yeast splicing pathway, particularly assembly of the spliceosome

  • M. C. Wahl, C. L. Will, R. Lührmann
  • EMBO J. 5,
  • 2009
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