The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes.

@article{Jiang2003TheEO,
  title={The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes.},
  author={Yong Jiang and Russell F. Doolittle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 13},
  pages={7527-32}
}
The blood coagulation scheme for the puffer fish, Fugu rubripes, has been reconstructed on the basis of orthologs of genes for mammalian blood clotting factors being present in its genome. As expected, clotting follows the same fundamental pattern as has been observed in other vertebrates, even though genes for some clotting factors found in mammals are absent and some others are present in more than one gene copy. All told, 26 different proteins involved in clotting or fibrinolysis were… CONTINUE READING
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