The evolution of tumor metastases during clonal expansion.

  title={The evolution of tumor metastases during clonal expansion.},
  author={Hiroshi Haeno and Franziska Michor},
  journal={Journal of theoretical biology},
  volume={263 1},
Cancer is a leading cause of morbidity and mortality in many countries. Solid tumors generally initiate at one particular site called the primary tumor, but eventually disseminate and form new colonies in other organs. The development of such metastases greatly diminishes the potential for a cure of patients and is thought to represent the final stage of the multi-stage progression of human cancer. The concept of early metastatic dissemination, however, postulates that cancer cell spread might… CONTINUE READING

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