The evolution of the thrombospondin gene family

  title={The evolution of the thrombospondin gene family},
  author={J. Lawler and M. Duquette and L. Urry and K. McHenry and T. Smith},
  journal={Journal of Molecular Evolution},
  • J. Lawler, M. Duquette, +2 authors T. Smith
  • Published 2004
  • Biology, Medicine
  • Journal of Molecular Evolution
  • SummaryThrombospondin-1 is an adhesive glycoprotein that is involved in cellular attachment, spreading, migration, and proliferation. To date, four genes have been identified that encode for the members of the thrombospondin gene family. These four genes are homologous to each other in the EGF-like (type 2) repeats, the calcium-binding (type 3) motifs, and the COOH-terminal. The latter has been reported to be a cell-binding domain in thrombospondin-1. Phylogenetic trees have been constructed… CONTINUE READING
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