The evolution of the thrombospondin gene family

@article{Lawler2004TheEO,
  title={The evolution of the thrombospondin gene family},
  author={J. Lawler and M. Duquette and L. Urry and K. McHenry and T. Smith},
  journal={Journal of Molecular Evolution},
  year={2004},
  volume={36},
  pages={509-516}
}
  • J. Lawler, M. Duquette, +2 authors T. Smith
  • Published 2004
  • Biology, Medicine
  • Journal of Molecular Evolution
  • SummaryThrombospondin-1 is an adhesive glycoprotein that is involved in cellular attachment, spreading, migration, and proliferation. To date, four genes have been identified that encode for the members of the thrombospondin gene family. These four genes are homologous to each other in the EGF-like (type 2) repeats, the calcium-binding (type 3) motifs, and the COOH-terminal. The latter has been reported to be a cell-binding domain in thrombospondin-1. Phylogenetic trees have been constructed… CONTINUE READING
    27 Citations

    Figures and Topics from this paper.

    Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity
    • 20
    Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins.
    • 57
    Thrombospondins: from structure to therapeutics
    • 52
    Bioinformatic analysis of adhesion proteins.
    • 14
    Thrombospondins and Novel TSR-containing Proteins, R-spondins, Regulate Bone Formation and Remodeling
    • 27
    Thrombospondin-1 is a multifaceted player in tumor progression.
    • 33
    • PDF
    Lack of thrombospondin-1 increases angiogenesis in a model of chronic inflammatory bowel disease
    • 28

    References

    SHOWING 1-10 OF 59 REFERENCES
    Cloning and sequencing of chicken thrombospondin.
    • 32
    A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome.
    • 90
    Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression.
    • 40
    Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.
    • 90
    Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.
    • 99
    • Highly Influential
    A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum.
    • 50
    • PDF
    Structure and chromosomal localization of the human thrombospondin gene.
    • 37
    • PDF
    The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins
    • 480
    • PDF