The evolution of the randomized controlled trial and its role in evidence-based decision making.

@article{Devereaux2003TheEO,
  title={The evolution of the randomized controlled trial and its role in evidence-based decision making.},
  author={P J Devereaux and Salim Yusuf},
  journal={Journal of internal medicine},
  year={2003},
  volume={254 2},
  pages={105-13}
}
The randomized controlled trial has been used in medical research for a little over half a century. This manuscript provides an overview of some of the history and evolution of the randomized controlled trial during this period. There exists hierarchies of evidence for therapeutic, diagnostic and prognostic questions, and the randomized controlled trial is… CONTINUE READING