The evolution of the nuclear receptor superfamily.

  title={The evolution of the nuclear receptor superfamily.},
  author={H{\'e}ctor Escriv{\`a} and St{\'e}phanie Bertrand and Vincent Laudet},
  journal={Essays in biochemistry},
Nuclear receptors form a superfamily of ligand-activated transcription factors implicated in various physiological functions from development to homoeostasis. Nuclear receptors share a common evolutionary history revealed by their conserved structure and by their high degree of sequence conservation. Here we review the latest advances on the evolution of nuclear receptors by addressing the following questions. What is known about the appearance and diversification of nuclear hormone receptors… CONTINUE READING

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