The evolution of spliceosomal introns: patterns, puzzles and progress

@article{Roy2006TheEO,
  title={The evolution of spliceosomal introns: patterns, puzzles and progress},
  author={Scott William Roy and Walter Gilbert},
  journal={Nature Reviews Genetics},
  year={2006},
  volume={7},
  pages={211-221}
}
The origins and importance of spliceosomal introns comprise one of the longest-abiding mysteries of molecular evolution. Considerable debate remains over several aspects of the evolution of spliceosomal introns, including the timing of intron origin and proliferation, the mechanisms by which introns are lost and gained, and the forces that have shaped intron evolution. Recent important progress has been made in each of these areas. Patterns of intron-position correspondence between widely… 
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