The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

  title={The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism},
  author={J. Engelman and J. Luo and L. Cantley},
  journal={Nature Reviews Genetics},
  • J. Engelman, J. Luo, L. Cantley
  • Published 2006
  • Biology, Medicine
  • Nature Reviews Genetics
  • Phosphatidylinositol 3-kinases (PI3Ks) evolved from a single enzyme that regulates vesicle trafficking in unicellular eukaryotes into a family of enzymes that regulate cellular metabolism and growth in multicellular organisms. In this review, we examine how the PI3K pathway has evolved to control these fundamental processes, and how this pathway is in turn regulated by intricate feedback and crosstalk mechanisms. In light of the recent advances in our understanding of the function of PI3Ks in… CONTINUE READING
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