The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients.

@article{Naesens2007TheEO,
  title={The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients.},
  author={Maarten Naesens and Neeraja Kambham and Waldo L. Concepcion and Oscar Salvatierra and Minnie M. Sarwal},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2007},
  volume={7 11},
  pages={2504-14}
}
To describe the evolution, risk factors and impact of nonimmune histological injury after pediatric kidney transplantation, we analyzed 245 renal allograft protocol biopsies taken regularly from the time of transplantation to 2 years thereafter in 81 consecutive rejection-free pediatric recipients of an adult-sized kidney. Isometric tubular vacuolization was present early after transplantation was not progressive, and was associated with higher tacrolimus pre-dose trough levels. Chronic tubulo… CONTINUE READING

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