The evolution of morphologic changes in the gallbladder before stone formation in mice fed a cholesterol-cholic acid diet.

Abstract

Mice were fed a lithogenic diet containing 1% cholesterol and 0.5% cholic acid, and the sequence of morphologic changes in the gallbladder was followed. Histologic changes were studied with light microscopy and cell proliferation with autoradiography. Mucus glycoprotein production was studied with a spectrum of glycoprotein histochemical stains and electron… (More)

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