The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones.

@article{Crisostomo2001TheEO,
  title={The evolution of methicillin resistance in Staphylococcus aureus: similarity of genetic backgrounds in historically early methicillin-susceptible and -resistant isolates and contemporary epidemic clones.},
  author={Melissa Crisostomo and Henrik Westh and Alexander Tomasz and Michelle Chung and Duarte C. Oliveira and Herminia de Lencastre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 17},
  pages={9865-70}
}
The key genetic component of methicillin resistance, the mecA determinant, is not native to Staphylococcus aureus. Thus, the evolution of methicillin-resistant S. aureus (MRSA) must have begun with the acquisition of the mecA determinant from an unknown heterologous source some time before the first reported appearance of MRSA isolates in clinical specimens in the U.K. and Denmark (in the early 1960s). We compared the genetic backgrounds and phenotypes of a group of methicillin-susceptible S… CONTINUE READING
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