The evolution of isochores

Abstract

One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.

DOI: 10.1038/35080577
0100200'03'05'07'09'11'13'15'17
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@article{EyreWalker2001TheEO, title={The evolution of isochores}, author={Adam Eyre-Walker and Laurence D. Hurst}, journal={Nature Reviews Genetics}, year={2001}, volume={2}, pages={549-555} }