The evolution of isochores


One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.

DOI: 10.1038/35080577
Citations per Year

1,399 Citations

Semantic Scholar estimates that this publication has 1,399 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{EyreWalker2001TheEO, title={The evolution of isochores}, author={Adam Eyre-Walker and Laurence D. Hurst}, journal={Nature Reviews Genetics}, year={2001}, volume={2}, pages={549-555} }