The evolution of gene regulation by transcription factors and microRNAs

  title={The evolution of gene regulation by transcription factors and microRNAs},
  author={K. Chen and N. Rajewsky},
  journal={Nature Reviews Genetics},
  • K. Chen, N. Rajewsky
  • Published 2007
  • Medicine, Biology
  • Nature Reviews Genetics
  • Changes in the patterns of gene expression are widely believed to underlie many of the phenotypic differences within and between species. Although much emphasis has been placed on changes in transcriptional regulation, gene expression is regulated at many levels, all of which must ultimately be studied together to obtain a complete picture of the evolution of gene expression. Here we compare the evolution of transcriptional regulation and post-transcriptional regulation that is mediated by… CONTINUE READING

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