The evolution of gene expression levels in mammalian organs

  title={The evolution of gene expression levels in mammalian organs},
  author={David Brawand and Magali Soumillon and Anamaria Necsulea and Philippe Julien and G{\'a}bor Cs{\'a}rdi and Patrick Harrigan and Manuela Weier and Ang{\'e}lica Liechti and Ayinuer Aximu-Petri and Martin Kircher and Frank Wolfgang Albert and Ulrich Zeller and Philipp Khaitovich and Frank Gr{\"u}tzner and Sven Bergmann and Rasmus Nielsen and Svante P{\"a}{\"a}bo and Henrik Kaessmann},
Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian… CONTINUE READING
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  • PLoS Biol. 9,
  • 2011

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  • Genome Biol. 11,
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