The evolution of class 1 integrons and the rise of antibiotic resistance.

  title={The evolution of class 1 integrons and the rise of antibiotic resistance.},
  author={Michael R. Gillings and Yan Boucher and Maurizio Labbate and A. J. Holmes and Samyuktha Krishnan and Marita P Holley and Hatch W Stokes},
  journal={Journal of bacteriology},
  volume={190 14},
Class 1 integrons are central players in the worldwide problem of antibiotic resistance, because they can capture and express diverse resistance genes. In addition, they are often embedded in promiscuous plasmids and transposons, facilitating their lateral transfer into a wide range of pathogens. Understanding the origin of these elements is important for the practical control of antibiotic resistance and for exploring how lateral gene transfer can seriously impact on, and be impacted by, human… CONTINUE READING
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