The evolution of cellular degeneration in dorsal root ganglia exposed to doxorubicin in tissue culture.

Abstract

Doxorubicin (Adriamycin) is a drug having both antibiotic and antimitotic properties. It intercalates between base pairs of DNA causing breaks in the helical strands. It is widely used as a cancer chemotherapeutic agent but is limited in use by a dose-related cardiomyopathy and necrosis of peripheral ganglia. This study of cultured mouse spinal cord and… (More)

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