The evolution of carrying capacity in constrained and expanding tumour cell populations

  title={The evolution of carrying capacity in constrained and expanding tumour cell populations},
  author={Philip Gerlee and Alexander R. A. Anderson},
  journal={Physical Biology},
Cancer cells are known to modify their micro-environment such that it can sustain a larger population, or, in ecological terms, they construct a niche which increases the carrying capacity of the population. It has however been argued that niche construction, which benefits all cells in the tumour, would be selected against since cheaters could reap the benefits without paying the cost. We have investigated the impact of niche specificity on tumour evolution using an individual based model of… 

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