The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes.

@article{Bergman2002TheEO,
  title={The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes.},
  author={Richard N Bergman and Diane T. Finegood and Steven E Kahn},
  journal={European journal of clinical investigation},
  year={2002},
  volume={32 Suppl 3},
  pages={35-45}
}
Insulin resistance and beta-cell dysfunction have important roles in the pathogenesis and evolution of type 2 diabetes. The development of precise methods to measure these factors has helped us to define the relationship between them and evidence is reviewed that changes in insulin sensitivity are compensated by inverse changes in beta-cell responsiveness such that the product of insulin sensitivity and insulin secretion (the disposition index) remains constant. While the disposition index… CONTINUE READING
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