The ever-expanding Ly49 gene family: repertoire and signaling.

  title={The ever-expanding Ly49 gene family: repertoire and signaling.},
  author={Stephen K Anderson and John R. Ortaldo and Daniel W McVicar},
  journal={Immunological reviews},
The mouse lectin-related Ly49 family and the human killer cell Ig-like receptor (KIR) family represent structurally distinct, yet functionally analogous, class I MHC receptors that are expressed on natural killer cells and some T cells. The functional similarity of these two families has been borne out by the demonstration of identical signal transduction pathways associated with each receptor family. The Ly49 family therefore provides a useful model system to study the role of this dass of… CONTINUE READING

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