The ever-emerging anti-inflammatories. Have there been any real advances?

@article{Rainsford2001TheEA,
  title={The ever-emerging anti-inflammatories. Have there been any real advances?},
  author={Kim Drummond Rainsford},
  journal={Journal of physiology, Paris},
  year={2001},
  volume={95 1-6},
  pages={11-9}
}
Gastrointestinal (GI) Adverse Drug Reactions (ADRs) from the NSAIDs are a major cause of morbidity and mortality in arthritic patients taking these drugs. The recent much heralded development of COX-2 selective drugs (celecoxib, rofecoxib), the objective of which has been to spare inhibition of the production of COX-1 derived mucosal protective prostaglandins, may have represented an advance in reducing the risk of serious ADRs--ulcers and bleeding--but does not appear to have reduced the… CONTINUE READING
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