The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation.

  title={The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation.},
  author={Ganesh Chandra Jagetia and Manjeshwar Shrinath Baliga and Krishna Jayacharya Malagi and M Sethukumar Kamath},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={9 2},
The effect of 0, 5, 6.25, 10, 12.5, 20, 25, 40, 50 and 80 mg/kg b. wt. of aqueous extract of triphala (an Ayurvedic herbal medicine) administrered intraperitoneally was studied on the radiation-induced mortality in mice exposed to 10 Gy of gamma-radiation. Treatment of mice with different doses of triphala consecutively for five days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug treated irradiated controls. The… 
Evaluation of the radioprotective action of geriforte in mice exposed to different doses of gamma-radiation.
It is demonstrated that geriforte is a good radioprotective agent and the optimum protective dose of 10 mg/kg was 1/475th of the LD50 dose.
Triphala, an ayurvedic rasayana drug, protects mice against radiation-induced lethality by free-radical scavenging.
Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW).
Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice
AME treatment reduced the symptoms of radiation‐induced sickness and increased survival, and the radioprotective action might be due to free‐radical scavenging and arrest of lipid peroxidation accompanied by an elevation in glutathione.
Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation
ACE was found to scavenge DPPH radicals in a concentration‐dependent manner, indicating that the radioprotection afforded by ACE may be in part due to the scavenging of reactive oxygen species induced by ionizing radiation.
Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study.
  • G. Jagetia, M. Baliga
  • Medicine, Biology
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2005
Fruit Extract of Aegle marmelos Protects Mice Against Radiation-Induced Lethality
Treatment of mice with AME before exposure to different doses of γ radiation reduced the severity of symptoms of radiation sickness and mortality with all exposure doses, and caused a significant decrease in the lipid peroxidation accompanied by a significant elevation in the GSH concentration in liver, kidney, stomach, and intestine of mice determined at 31 days postirradiation.
Rutin treatment protected mice against the gastro intestinal death as well as bone marrow deaths and free radical scavenging activity of the drug was evaluated to understand the possible mechanism of action of rutin.
Prophylactic Use of Alstonia Scholaris (Sapthaparna) against Gamma Irradiation
From the present study it is clear that Alstonia scholaris extract provides protection against radiation-induced deleterious effects of radiation.
Radioprotective Effect Of Alcoholic Extract Of Mentha Piperita (Linn) On Swiss Albino Mice Exposed To Whole Body Gamma Irradiation: A Preliminary Study
50% alcoholic extract of Mentha piperita (ALM) was tested for its radioprotective ability in terms of radiation sickness and survival of Swiss albino mice and was well tolerated at highest dose.


A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse.
Considering the low dose needed for protection and the high margin between the effective and toxic doses, the ocimum flavonoids may be promising for human radiation protection.
In vivo radioprotection by ocimum flavonoids: survival of mice.
Radical scavenging activity has been demonstrated for both orientin and vicenin, and this appears to be one of the mechanisms of protection by these flavonoids.
Radioprotective effect of antioxidative flavonoids in γ-ray irradiated mice
The results suggest that the radioprotective effect of flavonoids in mice may be attributed to the hydroxyl radical scavenging potency in a direct or an endogenous enzyme mediated manner.
Radiation Protection by the Ocimum Flavonoids Orientin and Vicenin: Mechanisms of Action
Free radical scavenging appears to be a likely mechanism of radiation protection by these flavonoids, which provided almost equal protection against radiation-induced lipid peroxidation in mouse liver.
Adverse effects of radioprotector WR2721.
It was concluded that at doses which were optimal for radioprotection (approximately 200 mg/kg) or lower, WR2721 increased in rats the taste aversion induced by radiation, by inference if conditioned taste aversion is an appropriate paradigm,WR2721 would increase nausea and vomiting in maninduced by radiation.
Protective Effect of αG-Rutin on Oxidative Stress in Mice
Results suggest that absorbed αG-Rutin works as an antioxidant in vivo by either scavenging reactive oxygen free radicals or forming a chelating complex with transition metal cations.
Protective effect of curcumin, ellagic acid and bixin on radiation induced toxicity.
The increased frequency of micronucleated polychromatic erythrocytes after whole body irradiation of mice was found to be significantly reduced with antioxidants.
Phytomedicine research in Germany.
  • H. Wagner
  • Biology
    Environmental health perspectives
  • 1999
In Germany since 1980, more than 300 clinical studies have been carried out with standardized phytopharmaceuticals, including Crataegus, Silybum, Ginkgo, Hypericum, Sabal, Urtica, Kava-Kava, Allium