The evaluation of data-derived safety factors for bis(tri-n-butyltin)oxide.

  title={The evaluation of data-derived safety factors for bis(tri-n-butyltin)oxide.},
  author={Andr{\'e} H. Penninks},
  journal={Food additives and contaminants},
  volume={10 3},
In this report the evaluation of a safety factor is assessed, according to the decision tree suggested by Renwick (1991a,b), to determine a Tolerable Daily Intake (TDI) value for the environmental contaminant bis(tri-n-butyltin)oxide (TBTO). Based on available literature the nature of the most sensitive parameter of TBTO-toxicity was perceived to be on lymphoid organs and lymphoid function. Subsequently, safety factors were derived in relation to published data on inter-species and inter… CONTINUE READING
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