The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors.

@article{Jiang2010TheEO,
  title={The evaluation of catechins that contain a galloyl moiety as potential HIV-1 integrase inhibitors.},
  author={Fan Jiang and Wei Chen and Kejia Yi and Zhiqiang Wu and Yiling Si and Weidong Han and Yali Zhao},
  journal={Clinical immunology},
  year={2010},
  volume={137 3},
  pages={347-56}
}
Four catechins with the galloyl moiety, including catechin gallate (CG), epigallocatechin gallate (EGCG), gallocatechin gallate (GCG), and epicatechin gallate (ECG), were found to inhibit HIV-1 integrase effectively as determined by our ELISA method. In our docking study, it is proposed that when the HIV-1 integrase does not combine with virus DNA, the four catechins may bind to Tyr143 and Gln148, thus altering the flexibility of the loop (Gly140-Gly149), which could lead to an inhibition of… CONTINUE READING
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