The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.

@article{Seminerio2013TheEO,
  title={The evaluation of AZ66, an optimized sigma receptor antagonist, against methamphetamine-induced dopaminergic neurotoxicity and memory impairment in mice.},
  author={Michael J. Seminerio and Rolf T. Hansen and Nidhi Kaushal and Han Zhang and Christopher R. McCurdy and Rae R. Matsumoto},
  journal={The international journal of neuropsychopharmacology},
  year={2013},
  volume={16 5},
  pages={1033-44}
}
Sigma (σ) receptors have recently been identified as potential targets for the development of novel therapeutics aimed at mitigating the effects of methamphetamine. Particularly, σ receptors are believed to mitigate some of the neurotoxic effects of methamphetamine through modulation of dopamine, dopamine transporters and body temperature. Furthermore, recent evidence suggests that targeting σ receptors may prevent cognitive impairments produced by methamphetamine. In the present study, an… CONTINUE READING