The evaluation and treatment of first-episode psychosis.

@article{Sheitman1997TheEA,
  title={The evaluation and treatment of first-episode psychosis.},
  author={Brian B. Sheitman and H. S. Lee and Rael D. Strous and Jeffrey A. Lieberman},
  journal={Schizophrenia bulletin},
  year={1997},
  volume={23 4},
  pages={
          653-61
        }
}
A first episode of psychosis is a traumatic experience for patients and families. At the time of initial evaluation, the differential diagnosis should include a broad range of neurological, general medical, and psychiatric conditions. Methodological advances in operationally defining illness onset, "offset," and remission have allowed more careful studies of treatment response in first-episode patients. These studies strongly support the efficacy of antipsychotic medication as both acute and… 
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92 Citations
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Results Citations
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92 Citations

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Citation Type

Duration of Untreated Psychosis and Clinical Outcome 1 Year after First-Episode Psychosis
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It is suggested that patients with a shorter duration of untreated psychosis tend to present more acutely, yet have a faster rate of recovery, than patients with the longer duration, especially when addressing long-term outcomes.
Analysis of clinical characteristics and antipsychotic medication prescribing practices of first-episode schizophrenia in Israel: a naturalistic prospective study.
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A prominent shift from "typical" to "atypical" antipsychotic medications may indicate sensitivity of first-episode psychotic patients to side-effects of "Typical" medications and prominence of use of atypical medications in this patient subpopulation be it due to improved efficacy over time or successful marketing.
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Patients with psychosis that is not responsive to pharmacotherapy may benefit from specific modalities of cognitive-behavioral therapy currently being developed, while persons with persistent negative symptoms and limited social competence may find social-skills training useful.
Symptom and demographic profiles in first-episode schizophrenia
Risperidone and haloperidol in first-episode psychosis: a long-term randomized trial.
TLDR
Relatively low doses of antipsychotic drugs lead to significant symptom amelioration in the majority of first-episode psychosis patients and in the long term, risperidone prevents relapse in more patients and for a longer time and also induces less abnormal movements than haloperidol.
Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables.
First-Episode Schizophrenia
TLDR
Safety concerns in this group of young patients, in the beginning of their first psychotic episode, are a major issue as they are starting a journey of antipsychotic treatment that is likely to last for the remainder of their lives.
A systematic review of longitudinal outcome studies of first-episode psychosis
TLDR
Outcome from FEP may be more favorable than previously reported, and treatment and methodological variables may be important contributors to outcome, and a multi-dimensional, globally used definition of outcome is required.
Treatment of first episode schizophrenia with low-dose haloperidol : a study in the Western Cape Province of South Africa
TLDR
The principal finding was that the majority of subjects could be stabilized and maintained on very low doses of haloperidol and ratings for extra-pyramidal side-effects did not increase significantly from baseline over the duration of the study, except in the case of tardive dyskinesia (TD), where a substantial number of subjects developed TD within 12 months of starting treatment.
Long-Acting Injectable Risperidone in the Treatment of Subjects With Recent-Onset Psychosis: A Preliminary Study
TLDR
This preliminary study suggests that RLAI was overall well tolerated and appears to be effective in recent-onset psychosis.
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