The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

@article{Hanks1995TheEP,
  title={The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1},
  author={Steven K Hanks and Tony Hunter},
  journal={The FASEB Journal},
  year={1995},
  volume={9},
  pages={576 - 596}
}
The eukaryotic protein kinases make up a large superfamily of homologous proteins. They are related by virtue of their kinase domains (also known as catalytic domains), which consist of ≈ 250‐300 amino acid residues. The kinase domains that define this group of enzymes contain 12 conserved subdomains that fold into a common catalytic core structure, as revealed by the 3‐dimensional structures of severed protein‐serine kinases. There are two main subdivisions within the superfamily: the protein… 
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