The etiology of otosclerosis: A combination of genes and environment

@article{Schrauwen2010TheEO,
  title={The etiology of otosclerosis: A combination of genes and environment},
  author={Isabelle Schrauwen and Guy Van Camp},
  journal={The Laryngoscope},
  year={2010},
  volume={120}
}
Otosclerosis is a common form of hearing loss characterized by abnormal bone remodeling in the otic capsule. It is a complex genetic disease, caused by a combination of genetic and environmental factors. During the past decade, several attempts have been made to identify factors for otosclerosis. This review provides an overview of the current understanding of the etiology of otosclerosis and describes the genetic and environmental factors that have been implicated in the disease. Environmental… Expand
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Otosclerosis due to abnormal bone homeostasis of the otic capsule is a frequent cause of hearing loss in adults. Usually, the hearing loss is conductive, resulting from fixation of the stapedialExpand
A seventh locus for otosclerosis, OTSC7, maps to chromosome 6q13–16.1
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A genome-wide linkage study was performed in a large Greek pedigree segregating autosomal dominant otosclerosis, and a seventh locus, OTSC7, was localized on chromosome 6q13–16 with a multipoint LOD score of 7.1. Expand
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A fifth locus for otosclerosis, OTSC5, maps to chromosome 3q22–24
TLDR
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