The etiology of methoxyflurane nephrotoxicity.

  title={The etiology of methoxyflurane nephrotoxicity.},
  author={M. Cousins and R. Mazze and J. Kosek and B. Hitt and F. Love},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={190 3},
  • M. Cousins, R. Mazze, +2 authors F. Love
  • Published 1974
  • Medicine, Chemistry
  • The Journal of pharmacology and experimental therapeutics
  • Treatment of Fischer 344 rats with phenobarbital prior to a low dose of methoxyflurane resulted in increased excretion of the methoxyflurane metabolites, inorganic fluoride and oxalic acid, increased urine flow rate and a greater degree of mitochondrial swelling in renal proximal convoluted tubule cells compared to that observed in rats treated with methoxyflurane alone. Pretreatment with SKF 525-A decreased the metabolism of methoxyflurane and ameliorated its nephrotoxicity, confirming the… CONTINUE READING
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