The ethics of excluding women who become pregnant while participating in clinical trials of anti-epileptic medications

@article{Beran2006TheEO,
  title={The ethics of excluding women who become pregnant while participating in clinical trials of anti-epileptic medications},
  author={Roy G Beran},
  journal={Seizure},
  year={2006},
  volume={15},
  pages={563-570}
}
INTRODUCTION The bioethical principles of autonomy, beneficence, non-maleficence and justice, complemented by ethics committee evaluation, define conduct of clinical trials of anti-epileptic medications (AEM). BACKGROUND INFORMATION Increased teratogenicity for offspring of women with epilepsy is presented in both lay and scientific literature. SPECIFIC DRUGS--OLDER GENERATION: Teratogenicity of phenobarbitone (PB), phenytoin (PHT), valproate (VPA) and carbamazepine (CBZ) is acknowledged… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 68 references

The teratogenicity of anti-epileptic drugs

LB Holmes, EA Harvey, +3 authors AM Hayes
N Engl J Med • 2001
View 5 Excerpts
Highly Influenced

Congenital malformations due to antiepileptic drugs.

Epilepsy research • 1999
View 4 Excerpts
Highly Influenced

Epilepsy: frequency causes and consequences

WA Hauser, DC Hesdorffer
New York: Demos Publications; • 1990
View 3 Excerpts
Highly Influenced

Malformation risksof antiepileptic drugs inpregnancy : a prospective study from the UK Epilepsy and Pregnancy Register

FC Fraser, JD Metrakos, M Zlatkin
J Neurol Neurosurg Psych • 2006

R,etal.Malformation risksof antiepileptic drugs inpregnancy: a prospective study from the UK Epilepsy and Pregnancy Register

MorrowJI, A Russell, +3 authors Waddell
J Neurol Neurosurg Psych 2006;77:193—8 • 2006
View 3 Excerpts

Similar Papers

Loading similar papers…