The ethical conduct of clinical research involving critically ill patients in the United States and Canada: principles and recommendations.

@article{Luce2004TheEC,
  title={The ethical conduct of clinical research involving critically ill patients in the United States and Canada: principles and recommendations.},
  author={John M. Luce and Deborah J Cook and Thomas R. Martin and Derek C. Angus and Homer A. Boushey and J. R. Curtis and John E. Heffner and Paul N. Lanken and Mitchell M. Levy and Paula Y Polite and Graeme M. Rocker and Robert D. Truog},
  journal={American journal of respiratory and critical care medicine},
  year={2004},
  volume={170 12},
  pages={1375-84}
}
Clinical research involving critically ill patients is necessary to reduce the extreme morbidity and mortality encountered in the intensive care unit (ICU). Yet such research is ethically challenging because critically ill patients usually are unable to consent for research participation, because conflicts of interest occur among investigators, and because discovering new knowledge while simultaneously protecting research participants from risk may be difficult to achieve. To explore these and… CONTINUE READING

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