The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats.

@article{Hu2013TheEE,
  title={The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats.},
  author={Ying Hu and Zhaobin Zhang and Libei Sun and Desheng Zhu and Qingchun Liu and Jian Jiao and Jun Li and Mingwen Qi},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2013},
  volume={53},
  pages={69-74}
}
Benzylparaben (BzP), a type of parabens being used as a preservative agent in cosmetics, food, and pharmaceutical products, may be ingested by humans. In this study, we performed an immature uterotrophic assay using Sprague Dawley (SD) rats by intragastric administration to determine the estrogenic effects of BzP and found significant increases in uterine weight with doses of 0.16 mg/kg body weight and higher (P<0.05). The in vivo estrogenicity of BzP was supported by in vitro results from the… CONTINUE READING

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