The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice

@article{VanSinderen2009TheEC,
  title={The estrogenic component of tibolone reduces adiposity in female aromatase knockout mice},
  author={Michelle L. Van Sinderen and Wah Chin Boon and Antwan G.H. Ederveen and Helenius Jan Kloosterboer and Evan R. Simpson and Margaret E. E. Jones},
  journal={Menopause},
  year={2009},
  volume={16},
  pages={582-588}
}
Objective: To explore the effects of tibolone on adiposity in the absence of aromatase and determine which of the hormonal properties of tibolone are exerting these effects. Methods: In this study, vehicle; tibolone; estrogenic (ethinyl estradiol [EE]), progestogenic (ORG2058), or androgenic (dihydrotestosterone) compounds; or a combination of ORG2058 + EE was administered to 6-month-old ovariectomized aromatase knockout (ArKO) mice for a period of 6 weeks. Results: In response to tibolone or… Expand
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