The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast.

@article{Collins1997TheEA,
  title={The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast.},
  author={Brendan M. Collins and J A McLachlan and Steven F. Arnold},
  journal={Steroids},
  year={1997},
  volume={62 4},
  pages={365-72}
}
We have used the expression of the human estrogen receptor (hER) and two estrogen response elements linked to the lacZ gene in yeast (YES) to study the estrogenic and antiestrogenic activities of various phytochemicals. Coumestrol, alpha-zearalenol, or genistein could produce beta-galactosidase activity comparable to estradiol, but these required concentrations 100 to 1000-fold greater than estradiol. These compounds did not possess antiestrogenic activity. Narigenin, kaempferide, phloretin… CONTINUE READING

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