The estrogenic activity of phthalate esters in vitro.

  title={The estrogenic activity of phthalate esters in vitro.},
  author={Catherine A. Harris and Pertti Henttu and Malcolm G. Parker and John P. Sumpter},
  journal={Environmental Health Perspectives},
  pages={802 - 811}
A large number of phthalate esters were screened for estrogenic activity using a recombinant yeast screen. a selection of these was also tested for mitogenic effect on estrogen-responsive human breast cancer cells. A small number of the commercially available phthalates tested showed extremely weak estrogenic activity. The relative potencies of these descended in the order butyl benzyl phthalate (BBP) > dibutyl phthalate (DBP) > diisobutyl phthalate (DIBP) > diethyl phthalate (DEP… CONTINUE READING
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