The estrogen-responsive B box protein is a novel regulator of the retinoid signal.

@article{Cheung2006TheEB,
  title={The estrogen-responsive B box protein is a novel regulator of the retinoid signal.},
  author={Belamy B. Cheung and Jessica L. Bell and Anna Raif and Andrew Bohlken and Joanne Yan and Ben Roediger and Anne Poljak and Stewart Smith and Michelle S. Lee and Wayne D. Thomas and Maria Kavallaris and Murray D. Norris and Michelle Haber and H Liu and Deborah A. Zajchowski and Glenn M. Marshall},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 26},
  pages={18246-56}
}
Retinoic acid (RA) induces growth arrest, cell death, and differentiation in many human cancer cells in vitro and has entered routine clinical use for the treatment of several human cancer types. One mechanism by which cancer cells evade retinoid-induced effects is through repression of retinoic acid receptor beta (RARbeta) gene transcription. The RA response element beta (betaRARE) is the essential DNA sequence required for retinoid-induced RARbeta transcription. Here we show that the estrogen… CONTINUE READING