The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis.

Abstract

Estrogen-related receptor alpha (ERRalpha) is one of the first orphan nuclear receptors to be identified, yet its physiological functions are still unclear. We show here that ERRalpha is an effector of the transcriptional coactivator PGC-1alpha [peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha], and that it regulates the… (More)

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Cite this paper

@article{Schreiber2004TheER, title={The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis.}, author={Sylvia N. Schreiber and Roger Emter and M. Benjamin Hock and Darko Knutti and Jessica A Cardenas and Michael Podvinec and Edward J. Oakeley and Anastasia Kralli}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={2004}, volume={101 17}, pages={6472-7} }